Summer is over for Peter Parker and school's ready to start - both literally and in the real world of crime-fighting - as Spider-Man faces his first real challenge, the Enforcers, and his first real super-villain, Vulture.

Peter Parker attempts to tutor the popular Liz Allan while Spider-Man tries to stop Electro, who will stop at nothing to find a cure for the accident that made him who he is.

Peter Parker and Spider-Man both must learn to own their choices when decisions made by Dr. Curt Connors transform Pete's mentor into the Lizard.

While Peter takes on the responsibility of helping Aunt May pay the bills while Montana, one of the Big Man's Enforcers, becomes the stunning Shocker to fulfill his responsibility: Eliminating Spider-Man.

Flint Marko is transformed into the invincible Sandman. Meanwhile, Peter risks compromising his cover and break Harry's heart by taking part in the school's American football try-outs. Gwen hopes Peter will take her to the formal dance.

Otto Octavius creates the Rhino in order to occupy Spider-Man. Meanwhile, Aunt May arranges to introduce Peter to Mary Jane Watson.

Peter Parker and Mary Jane Watson go to the Midtown High Fall Formal. Meanwhile, the mysterious Green Goblin tries to force L. Thompson Lincoln to step down as NYC's Big Man of crime. Will Spider-Man be able to take on this new threat?

Peter and Spider-Man learn that their actions have consequences when Otto Octavius becomes the supervillain Doctor Octopus following a lab accident caused by the Green Goblin.

While Colonel John Jameson struggles to land his damaged space shuttle, Spider-Man struggles to defeat the Green Goblin, who also threatens Hammerhead and Tombstone.

Spider-Man encounters master thief Black Cat and bonds with an alien symbiote, granting him enhanced abilities. Meanwhile, the Chameleon impersonates Spider-Man, forcing the real Spider-Man to join forces with Black Cat to stop him.

With May hospitalized and his friendship with Eddie ruined, Peter gains enough self-awareness to realize the symbiote is affecting his personality. The struggle between Peter and the symbiote evolves into a war within Peter's own mind.

As May is released from the hospital, Eddie, now transformed into the vicious Venom after bonding with the symbiote, seeks revenge on Peter by targeting his loved ones, including May and Gwen, drawing Spider-Man into motion to defeat him.