Sung, Hooten and Villanueva join forces to convince Trisha Miller (guest star Cozi Zuehlsdorff), a 13-year-old girl with an advanced brain stem glioma, to try surgery one last time before giving up.

Sung is forced to meet with Risk Management's Fran Horowitz (guest star Valerie Mahaffey) after refusing to apologize to the wife of a patient who died on his table.

Tina's proposal to use an unorthodox procedure to treat a young man with extreme O.C.D. divides the surgeons at the 311 conference.

Hooten's mentor, Dr. Arvin Wayne (guest star Hal Holbrook), walks into the wrong procedure on the wrong day, leading the surgeons at Chelsea General to question the cognitive abilities of one of the hospital's elder statesmen.

Ty and Tina receive a late night call from Afghanistan, where Corpsman Jacob Gold (guest star Reiley McClendon) desperately needs help when his fellow Marine suffers a traumatic head injury.

During Monday's 311 conference, Hooten calls Dr. Stewart Delany (guest star Ioan Gruffund) to explain how a careless mistake killed Delany's young patient. But the outcome of the conference leaves the hospital's surgeons conflicted.

Ty and Hooten believe Supreme Court hopeful Judge Beverly Nathenson's facial pain is the result of a brain tumor; upon operating, the surgeons discover a diagnosis much more shocking.