Matty splits the team up for a mission, and partners the teammates with their fellow teammates they had the most problems with during the Codex affair.

When Taylor's former protégé is killed while preventing a bio-weapon from falling into the wrong hands, Mac and the team must find the weapon so Desi can pull off the ultimate heist before it's sold to a terrorist cell.

When Russ is kidnapped, Mac and the team must break out a previously murderous psychopath, now pacifist, from prison to help find him. Also, while on the run, Mac and Desi are forced to confront their relationship issues.

Mac's meeting with Desi's parents goes sideways when her brother finds himself in trouble and desperately needs their help. Russ and Matty must ask an old nemesis for assistance when their new recruitment candidate is kidnapped.

Using a cryptic postcard as their only clue, Mac and the team must solve a fallen friend's final case and bring him justice

During COVID-19's first stay-at-home order, as Mac, Bozer and Riley quarantine together, they try to stop a crime in progress at their neighbor's house.

The secret experimental cancer treatment Mac's developing with a friend is discovered when culprits ransack their lab, kidnap Mac's partner and plan to use the research to create a powerful new nerve agent.

Mac and team rush to help when Matty's former mentor, Ian Cain, and his embassy staff come down with a deadly, mysterious illness. Also, Taylor and Bozer work with Jerry Ortega.

When Mac and the team are unable to prevent Department of Defense intel from falling into Codex's hands, Mac must scale a vertical cliff using only gear he can cobble together himself to prevent the info's transmission

Murdoc teams up with Andrews to hack the team's comms and reveal their most closely-guarded secrets to each other.

Mac and Riley head overseas together to prevent a governmental collapse and inadvertently inhale new deadly microscopic technology

Mac, Desi, and Russ crash a royal wedding to protect the bride, and try to work out their own romantic issues.

Mac and Desi trace a rare car to Italy, hoping it leads them to the criminal who used to own it.

Mac and Wilt travel to their hometown to visit Wilt's family. Meanwhile, Riley and her hackers try to get a leader on the nano-trackers.

When Mac and Riley go missing and wake up 24 hours later in a corn field with no memory of how they got there, they must unravel the mystery to find who took them, and how to get rid of the nanotrackers in their bodies, no matter the cost,