A secret sect of the Vatican Church unearths a map detailing the locations of the four cornerstones of the Library of Alexandria; Flynn and the Librarians work with an unexpected ally to stop them before the stones can be used to destroy the Library.

When people begin getting hurt in the unluckiest of ways, the Librarians are led to a casino where the owner appears to possess an artifact capable of stealing people's luck.

After the world is morphed into a horrible and unrecognizable place - one where the Library never existed - it's up to Baird to bring the Librarians together before this bleak, knowledge-less world becomes the new reality.