Max and Sharpe go public with their relationship at the hospital; the team struggles to keep a handle on an overcrowded and understaffed ICU and everyone must pitch in; Iggy's overly critical feedback alienates his residents.

Max advises a young student at a science fair but encounters legal complications with her brilliant invention. Bloom encourages Dr. Shinwari to be more aggressive in the ED.

Max struggles with a new fiscal reality at the hospital; Dr. Sharpe is on a mission to provide follow-up cancer screenings for patients before it's too late; Bloom grapples with Dr. Shinwari's new overnight schedule.

Dr. Fuentes continues her quest to remake the hospital in her vision; Max goes the extra mile to help a patient in need; Dr. Sharpe and Iggy find themselves at odds over a serious issue.

Dr. Reynolds and Dr. Malvo have a heart-to-heart with Dr. Baptiste. Max learns a little more about Sharpe when someone from her past resurfaces. Iggy plays referee between two young patients and their families.

Max is shocked when a deadly ambulance crash reveals a dangerous plan. Fuentes pressures Iggy to see patients. Sharpe realizes cost cutting has adversely affected the hospital. Reynolds, Baptiste and Malvo try to reach an accord.

Max is faced with a wrenching decision when New Amsterdam falls prey to a massive ransomware attack.

Max takes drastic measures to help several undocumented immigrants.

As Max and Dr. Sharpe prepare to depart for London, a deadly super bug hits the hospital.

Max and Helen adjust to sharing their lives and their problems, including the challenge of Helen's mother; Bloom and Reynolds treat a family after their horrific car accident lands them in the ED; Iggy and Trevor reach a new understanding.

Max formulates a bold plan to help New Amsterdam before it's too late. Reynolds and Dr. Fuentes argue over the best way to handle a risky surgery. Dr. Wilder asks for Dr. Castries for help with a patient with terminal cancer.

The New Amsterdam team continues to deal with the consequences of their big night out; Max and Helen discuss options for their future; Martin finally learns Iggy's secret; Bloom helps Leyla avoid a life-changing situation.

Max orchestrates a plan to get Dr. Fuentes terminated from New Amsterdam once and for all; Helen confronts her medical complication; Iggy helps two patients deal with a breakup, which forces him to consider his own marriage.

Max discovers a fatal flaw in Dr. Fuentes' scheme to purchase the UMI medical clinic, which could be her ultimate undoing, Dr. Bloom treats two high school students and Helen learns more about her Mum.