Jackson Oz finds a link between his late father's theories and mysterious animal attacks.

Jackson's best friend, Abraham, thinks lions might be killing humans for sport.

Jackson, Jamie, and Chloe travel to Mississippi to investigate the prison fire, while Abraham and Mitch go north to trap and study wolves.

Abraham works to save Chloe and Mitch from a drug lord; Jackson and Jamie continue to work with Agent Shaffer in search of Evan Lee Hartley and the Mother Cell after Leo is killed in the crash.

After a cargo ship comes to shore in Massachusetts, rats invade the island; Mitch makes a visit to his daughter and prepares to get the cure to her terminal illness.

Now fugitives, the members of the team head to Zambia with the ultimate goal of manufacturing a cure for abnormal behavior; Chloe makes a sacrifice.

Chloe is taken hostage by someone she knows. Jackson and the others are arrive at Zambia to find the leopard to test Mitch's theory of the animal mutation.

Chloe tries to bring light to the rising threat from the animals. Jackson is taken to a hospital and while they are there Mitch works to create a cure. However, there are many obstacles they must overcome.

Jackson and the team make a final attempt to find a cure to the worldwide animal pandemic, but hit an obstacle that may be impenetrable.