Quinlan and Fet discover that stealing a nuclear warhead isn't easy when they encounter an unexpected enemy. Eph and Alex concoct a new weapon to use against the strigoi. Frustrated with his seclusion, Zack discovers a love interest.

Fet and Quinlan have to figure out how to get the nuclear bomb back to New York, while a desperate Eichhorst draws near. Love struck Zack tries to learn more about his new crush, but makes a devastating discovery.

His health failing, Setrakian ignores Eph's warnings, pushing himself to the limit in his quest for victory and revenge. Fet and Quinlan race back to Manhattan, while the Master seals off the city and prepares to eliminate them all.

Reeling from loss, our heroes regroup. To defeat the Master, they must locate him first. Our heroes devise a new plan to track him through human collaborators, beginning at the blood farm with someone Dutch knows all too well.

An unexpected guest brings old conflicts to the surface, dividing our heroes, threatening the group's trust. With questionable new intel in hand, they launch a make or break final assault on the Master.