Sam and Dean Winchester were trained by their father to hunt the creatures of the supernatural. Now, their father has mysteriously disappeared while hunting the demon that killed their mother, 22 years ago.

Sam and Dean make a stop at Blackwater Ridge and end up helping a young woman and her brother find their other brother, who mysteriously disappeared, while on a camping trip, in the woods.

Something in the lake of a small town is killing innocent people.

A friend of John's calls Sam and Dean for help about a strange recording on the black box of a crashed plane. They soon realize that the demon which caused the crash is picking off the crash's only seven survivors.

A game of Bloody Mary unleashes a ghost who lives in mirrors and kills by gouging out the eyes of her prey, Sam and Dean must find a way to stop her before she claims another victim.

A serial killer shape-shifter adopts the likeness of Sam's college buddy to commit a gruesome murder. When the brothers investigate, the being "borrows" Dean's form to continue the killing spree.

Sam and Dean investigate an age-old urban legend known only as the Hook-Man, the spirit of a 19th-century pastor with a twisted sense of morals that is unknowingly being used as an innocent girl's attack dog.

Sam and Dean head to Oklahoma to investigate a recent spate of insect-related deaths around a new housing development.

After arguing about the search for their father, Sam and Dean split ways - Sam to continue the search in California, Dean to hunt the mysterious disappearances of passing-through couples in Indiana.

Dean is contacted by an ex-flame who asks him for help when black men in her hometown are being murdered by a driver-less racist truck.

When Sam's visions start happening while he's awake, he and Dean investigate the unusual murders he foretold only to find them all to be true. And that perhaps he's not the only one with special abilities.When visiting the Millers the boys go as priests.

After following a history of disappearances in Hibbing, Minnesota, Sam finds himself locked in a cage and Dean must team up with a by the book sheriff to find him......before the hunt begins.

When a case of a seemingly average haunting begins to go haywire, Sam and Dean come to find that two bumbling, wanna-be paranormal investigators, Harry and Ed, are already on the case.

Dean gets a second chance to right a wrong from his past when the brothers get a mysterious tip from their father about a case they'd worked years ago, but left unfinished after Sam was nearly killed by the creature.

When two sets of owners of the same painting are brutally murdered, Sam and Dean investigate with the help of an auction house owner's daughter, all while Dean shamelessly tries to pair her with his little brother.

After John's mentor, a vampire hunter, is murdered, John shows up to help his sons solve the case. The vampires have taken an antique gun with supernatural powers. The Winchesters set out to retrieve the gun.

Meg turns to killing John's friends in order to get the Colt. Sam and Dean stake out the Demon's next target; a family with a six-month-old baby shows signs of special abilities. John heads off alone to confront Meg.

Sam and Dean seek help from Bobby Singer, an old family friend in their mission to save their father from Meg. The brothers set a trap for Meg.