Lanning and Keating work together to save the life of a newborn baby; Keating faces a medical scare that could prevent her from having children; Brennan helps a man whose father has cancer deal with his impending death.

Collette treats a firefighter with serious burns; Brennan refocuses on making her marriage work and ending her affair with Dr. Kokoris.

Lanning and Keating treat a trouble young girl who wants to be sterilized; Jordan and her physician husband clash with how to get the mother of an obese boy to take her son's health seriously.

Rae tries to persuade the parents of a boy with sickle-cell anemia to tell him he has the disease; Matt agrees to donate sperm to fertilize Jules' eggs; Harriet attempts to convince a woman with heart problems to deliver her baby early.