San Antonio Memorial's iconoclastic doctors and nurses use their instincts and combat experience to defy the odds and run the chaotic emergency room night shift.

A dying sheriff's deputy leaves TC (Eoin Christopher Macken) facing giving him a heart transplant for the second time. Landry's (Daniella Alonso) child abuse investigation produces a startling diagnosis.

Injuries at an Alamo reenactment test the staff. Meanwhile, a disorientated patient suffering from amnesia receives care; Drew helps a severely wounded soldier; Topher schedules a vasectomy operation; and Jordan's boyfriend arrives.

The aftermath of a serious military bus accident threatens to expose the truth about Drew's (Brendan Fehr) relationship with his boyfriend, Rick. TC (Eoin Christopher Macken) and Scott (Scott Wolf) square off over Jordan (Jill Flint).