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SummaryMarshall (voiced by Dave King) and Frances (voiced by Emily Pendergast) are former high school lab partners who battle drug companies and the DEA after Marshall discovers a mushroom that can cure almost any ailment in the animated series from Joe Bennett, Steve Hely and executive producers Greg Daniels, Dustin Davis and Mike Judge.

Common Side Effects

Season 1 Premiere: 
Feb 2, 2025
Metascore
Generally Favorable
80
User score
Universal Acclaim
8.5
My Score
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Metascore
Generally Favorable
80
100% Positive
6 Reviews
0% Mixed
0 Reviews
0% Negative
0 Reviews
  • All Reviews
  • Positive Reviews
  • Mixed Reviews
  • Negative Reviews
Jan 27, 2025
83
The A.V. Club
Common Side Effects is a compelling blend of suspense, spirituality, understated comedy, and just enough mystery dangling on the hook. And in a healthier television landscape, there would be more shows like this one, an original work that feels no pressure to be a loud spectacle.
Feb 3, 2025
80
Decider
Common Side Effects is definitely more thriller than comedy, but there are enough funny moments to lighten the mood as things get more complex and serious by the third and fourth episodes. Once we get to that point, though, it’s a surprisingly gripping thriller that keeps viewers engaged.
User score
Universal Acclaim
8.5
93% Positive
70 Ratings
1% Mixed
1 Rating
5% Negative
4 Ratings
  • All Reviews
  • Positive Reviews
  • Mixed Reviews
  • Negative Reviews
Feb 14, 2026
10
khomazz
ansiose pela proxima temporada aaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaaa
Jun 21, 2025
10
cuuuuuuuuuube
It is a unique show, with highest quality of plot, characters and idea. Much better than Rick and mortyor or any other adult animated series.
Jan 31, 2025
80
Los Angeles Times
While the story could conceivably be told with live actors in real settings, it would likely be so exaggerated, so satirical, that the human element, paradoxically, might get lost. Animation keeps it humble, believable and meaningful. This is all a function of good writing and underplayed acting; the mood is largely deadpan.
Jan 30, 2025
80
Wall Street Journal
Created by Steve Hely and Joseph Bennett, the animated series is a wry, stylized thriller about a murderous conspiracy against a disruptor of the status quo. Not an entirely new idea. But a cartoon take on corporate skullduggery and incompetent government investigations is fresh enough to grab you by the collar of your Hawaiian shirt—the wardrobe go-to of Marshall Cuso.
Jan 30, 2025
80
The New York Times
As a conspiracy thriller, “Common Side Effects” is decidedly an ordinary button mushroom. In the four episodes screened for critics, the action twists are familiar and the members of its shadowy cabal underdeveloped. What makes the series captivating is its style and deadpan voice.
Jan 27, 2025
80
IGN
We’ve only seen four episodes so far, but Common Side Effects has the potential to be one of the greatest Adult Swim shows of all time – as long as it can learn to calibrate a comedic sensibility that sometimes clashes with the seriousness of its subject matter.
See All 6 Critic Reviews
Apr 7, 2025
10
bertobellamy
An astounding black comedy and thriller about the dark underbelly of the pharmaceutical industry. Visually and narratively sublime. The season finale is a mind-bending marvel that finally embraces the story's most surreal essence (with scenes reminiscent of 'The Substance,' 'Men,' and 'Interstellar'). The best animated series nowadays.
Apr 1, 2025
10
BossHog021
What a treat of a show. Common Side Effects feels like a great mix of humor, very interesting storyline, and weirdness. On top of that the animation is so unique and well done. Anything Mike Judge has been attached to has been amazing and this is no different.
Mar 31, 2025
10
johndoe2014
This is the best show on TV. Excellent on all levels. It is not afraid to get real. At the same time it is 100% entertaining and exciting. Everything Mike Judges touches is gold. This is another example, and maybe the best show he's involved in yet.
Mar 31, 2025
2
night4
Just terrible. Being animated does nothing for the show. Voice acting is tolerable, but everything else is painful to experience. You may as well just listen to a conspiracy theorist's podcast instead because it's about the same thing.
Mar 17, 2025
0
Randori3
[SPOILER ALERT: This review contains spoilers.]
See All 75 User Reviews
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  • Bandera Entertainment
  • Green Street Pictures
  • Hely Enterprises
  • Le Cube
  • Williams Street
Feb 2, 2025
2 Seasons
TV-MA
Annie Awards
• 4 Wins & 5 Nominations
Golden Tomato Awards (Rotten Tomatoes)
• 3 Nominations
Annecy International Animated Film Festival
• 1 Nomination
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