Sena Kobayakawa manages to enter Deimon High, the same school his friend Mamori Anezaki is currently attending. On his first day, all goes well until he runs into three bullies known as The Ha-Ha Brothers.

Sena arrives at school early to do some training. Sena manages to recruit Tetsuo Ishimaru to the team, while Hiruma retrieves the rest. They are now ready to play American Football.

It is Eyeshield 21's debut game -- a match against the Koigahama Cupids, whose players often bring their girlfriends to their game. Shin and Sakuraba from the Ojo White Knights also appear as spectators, recording the game.

The Deimon Devil Bats have won their first game of the year. However, their next match is against the Ojo White Knights, one of the best teams in Japan. Also, Mamori is accepted to join the American Football Club as manager.

Intimidated by the imposing statures of the White Knights players, Sena thinks of quitting American Football. Kurita reminds him that he has guards around him, so things will be alright.

The Deimon Devil Bats are up 6-0. However, the Ojo White Knights' ace linebacker Shin is put into play, turning the tide in favor of the White Knights.

The Deimon Devil Bats are in trouble once Shin joins the game. Eyeshield 21 does not want to play any longer after suffering from Shin's Spear Tackle. The White Knights' Sakuraba, on the other hand, has to decide between the game or fame.

The Deimon Devil Bats are already sure to lose the game, but Eyeshield 21 is still determined to get past Shin.

Sena walking to school holding a football. A baseball lands at his feet and Raimon "Monta" Taro comes to retrieve it. When told to give Monta the ball, Sena throws the football, but it slips from his hand.

In the previous match between the Devil Bats and the White Knights, Eyeshield 21 accidentally ran over Sakuraba, causing Sakuraba to be hospitalized. Hiruma poses as Eyeshield 21 and taunts that the accident was not accidental.

Hiruma has just arranged a practice match against the Zokugaku Chameleons, a team notorious for dirty play and led by linebacker Rui Habashira, who has extremely long arms.

It is the Deimon Devil Bats vs the Zokugaku Chameleons. After being tackled by Habashira, Sena starts imagining Habashira being everywhere, thus becoming petrified.

Eyeshield 21 watches as Monta gets up after being tackled again and again. Monta puts on a brave face and encourages Sena despite being heavily battered and barely able to walk straight.

Due to a great number of applicants for the American Football Club, Hiruma decides to hold a try-out. He rents the Tokyo Tower for the whole day.

Hiruma realizes that Eyeshield 21 has good acceleration but bad stamina, so he asks all Deimon students to hunt down Eyeshield 21 or he will spread scandalous information about them.

Kurita has been accused by shop owners of ruining their decorations for a festival. Knowing that the Devil Bats will be disqualified for the Christmas Ball if one of the members has to face disciplinary action, Kurita withdraws from team.

The Deimon Devil Bats are going to hold a barbecue lunch. However, it is still part of the training Hiruma wants to give the new teammates. Hiruma orders them to memorize passing routines for football.

A magazine publishing company needs a Japanese football team to compete against an American team, and thus holds a contest for it.

It is a game between the Sphinx and the Devil Bats for the right to represent Japan against the Aliens. The Sphinx prides itself on the heaviest line in Japan.

When the going gets tough for them, the Sphinx reveals their secret weapon: a freshman called Kamaguruma who uses his "chariot bump" against Monta in order to stop Monta from catching Hiruma's passes.

The Devil Bats are trailing to the Sphinx. Hiruma insists that Monta catches his passes, reminding Monta that the outfield is his backyard. The match ends with a draw.

A sixteen-year-old expert inline skater and part-time reporter named Taki Suzuna is searching for Eyeshield 21's real identity, stalking the Devil Bats team. She challenges him to race her.

The American team accepts the game against the Deimon Devil Bats. Sena and a man called Panther each learn how fast the other is. Wanting to go up against each other, they do their best to ensure total victory for their team.

The NASA Aliens and the Deimon Devil Bats are ready for their game, but unless the blitz works, Deimon learns they will be deported from Japan. Can Sena use his speed to stop the tag team duo of Homer and Watts?

Trailing 14-6, Deimon has managed to stop the Shuttle Pass and is slowly progressing the ball with the sweep, but Sena wants to embarrass the Aliens and allow Panther on the field. Will Panther finally get his time to shine?

Trailing 26-21, the NASA Aliens finally unleash Panther and their new Moonsault Formation. Shin watches eagerly as he realizes a new speedster could threaten his reign.

Hiruma drags his team out of Japan to Houston for a boot camp. He brings Cerberus with him, asking Sena to look after the dog. On the airplane is a little girl who has a stuffed toy that looks like Cerberus.

When Sena and Monta get lost in America, they end up at a football field where Panther learned to play. Panther's grandmother notices how well they can play, and asks if they could play with their team.

Hiruma orders the members of Devil Bats to go to the beach. Sena, Mamori, and Monta come across the Seibu Wild Gunmen's coach and Kid.

The Bats are resting at the Wild Gunmen ranch. The coach has agreed to train them. Hiruma mentions that Deimon does not allow extracurricular activities after the second year so it is his and Kurita's last chance for the Christmas Bowl.

The death march training begins. Monta and Yukimitsu must run routes while Hiruma shoots them. The defensive linemen must push a truck. Sena has to kick a rock across the whole 2000 km.

The training and the heat intensify as the team treks across Texas, but when the situation continues to get rougher, it could lead to one or two people trying to quit altogether. Is this the end of the Devil Bats' training?

Sena accidentally kicks the rock into a motorcycle gang. Knowing that he will have to run the whole Death March again if he loses it, he runs after them, and gets separated from the rest of the team.

Sena applies all the training from the death march in the match. When he scores the winning goal, Sena's last opponent declares that he saw a ghost beside Sena as he ran.

Yukimitsu collapses during the run. If he does not complete the run, he will be dropped from the team.

The Devil Bats truck gets stuck in a pothole; with one final push together as a team, Deimon overcomes the last obstacle. Arriving in Las Vegas, on the pirate boat outside Treasure Island, Doburoku confronts Sena.

The Devil Bats return to Japan, but Hiruma informs them that Ojo lost to Shinryuji. Meanwhile, Sakuraba reaches a breaking point and seriously considers his future as a football player.

The Deimon Devil Bats have returned home. Hiruma must decide on the regular players. Everyone but Yukimitsu is chosen. Yukimitsu will continue to be a bench player.

While hiding from a group of television interviewers, Suzuna questions why Sena does not tell Mamori who he is.

Kurita and the other Devil Bats learn that one loss means their entire dream will end. Once he gets home, Kurita goes into hiding, not wanting to be the cause of the Devil Bats' failure. Can the others convince him to come out?

Deimon are up against Amino, a school where they use medical science to increase their muscle sizes. They are all artificial muscles. Sena follows "idiot" Taki onto the wrong bus and ends up to a faraway place, Nagano

Chameleon Habashira Rui gives Sena a lift to the stadium on his motorcycle. In the game, Amino decides to target Monta and tackle him on offense and defense.

Monta and Sena are reluctant to recruit the legendary kicker "60 yard Magnum" Musashi back onto the team.

Taki must pass the entrance exam to be able to play for Deimon.

Hiruma forbids Sena to use the Devil Bat Ghost until a real game in order to keep spies from getting looks at it.

Now substituting in a corporation league game, Sena and Shin finally get the rematch they've been waiting so long for. However, Shin is disappointed as Sena refuses to use the Devil Bat Ghost due to his previous orders from Hiruma.

The Devil Bats witness the prowess of their next opponents, the Yuuhi Guts; Hiruma says that the Devil Bats have a great chance of winning, but the Yuuhi Guts have a small chance of defeating them due to more experience.

It's Deimon vs. Guts, but the Guts' coach has replaced all the regular players with the best players from other teams.

The Devil Bats meet the captain of the Hashiratani Deers, Yamamoto Onihei; the Devil Bats scout their future opponents by taking in the Deers vs. Kyoshin Poseidon game.

Sena learns the truth about Eyeshield 21 from a Poseidon player, Kakei Shun; Sena learns from Shin that it isn't size that matters, but an unwavering spirit.

Eyeshield 21 goes to the Chameleon's locker room and destroys the players uniforms.

Chameleon and Poseidon play their game.

Sena and the Devil Bats play their game with the Dokubari Scorpions, who consider football just as much of a mind game as a physical one; however, their captain Kanagushia fails to take into account Hiruma's tactics.

With Hiruma MIA and the Scorpions on the lead, it looks like the Deimon team's Christmas Bowl dreams are over; until Mamori remembers the game plan Hiruma entrusted to her.

With the game with the Scorpions behind them, Deimon prepares to play the Kyoushin Poseidons; however, it may be without one of the linemen, Komusubi has run away.

Komusubi starts learning sumo; with his training, he finds a way to overcome the physical difference between himself and Mizumachi and Kakei.

When Monta and Sena are sent to spy on the Poseidons' final practice before the game, they are caught, and Kakei tells Sena that he wants to challenge Eyeshield 21.

Sena and the Devil Bats start their game against Mizumachi and the Kyoushin Poseidons.

Sena finds it difficult to run against the Kyoushin team, so it's up to Hiruma to lead his team down the field.

The Devil Bats make a comeback, the score is 14-12, and Deimon has the ball.

The game continues with a stalemate with both teams trying to break the trend and score, knowing that this will lean the game highly in their favor.

With pressure by the Devil Bats, Mizumachi and Shun conclude that it's time to unleash the true power of the Kyoushin defense.

With the game and their tournament hopes in the balance, Sena and the Devil Bats get help from an unlikely source.

Riku appears and talks about his past and how Sena could run because of him.

Hiruma takes advantage of the school's field day to make it a training session for the team.

Ishimaru and the track team need an extra man, so they ask Sena to help out; seeing if Sena keeps his secret.

As the time approaches for the game against the Seibu Wild Gunmen, Hiruma, Kurita and Musashi all recall the promise they made to go to the Christmas Bowl.

The game with Seibu begins; the Devil Bats get all they can handle from their running back, Kaitani Riku, the boy that taught Sena how to run.

With the triple threat of Riku, Tetsuma, and the Kid bearing down on the Devil Bats, it looks like their luck may have run out.

After seeing the dire straits the Deimon team is in, and a stern talking to from his father, Musashi rejoins the Devil Bats.

Finally, with all the Devil Bats on the field, Hiruma can unleash the true power of the Devil Bats, seeing if it is enough to overtake the Seibu team.

As the Deimon-Seibu game goes on, Sena finds out that he's more than a match for his friend Riku and brings the Devil Bats close to victory with his Devil Bat Tornado.

Kid tells Hiruma that he fell directly into his trap and that everything is always too good to be true.

After losing to the Seibu Gunmen, Tetsuma rescues Monta from getting Deimon suspended from playing.

The Bando Spiders face off against the Ojo White Knights.

Deimon realizes that they will need a kicker to win their game against the Bando Spiders.

Sena and Suzuna go to retrieve their helmets and cleats at a store where Sena sees a helmet with an eye shield on it.

Mamori tries to help Sena, but Sena can't find enough time to transform into Eyeshield 21.

Before the match, Sena removes his helmet to reveal his identity to the world; Mamori accepts who Sena is; the game against the Bando Spiders begins.

Using a trick kick in the beginning of the game, Akaba recovers the ball and Kotaro scores a field goal.

The game continues to turn in the Spiders' favor, as they score yet another field goal, giving them a 20-point lead.

Using a combination run with Hiruma, Sena is finally able to score a touchdown.

Musashi arrives just in the nick of time and scores a 45-yard field goal, and Deimon is now only behind by eleven points.

With the wind's speed increasing, passing becomes impossible; Deimon is left with no other choice but to have Sena run the ball.

Taki begins to cause problems for the Devil Bats in the critical fourth quarter of their game against the Spiders.

With four minutes left in the game, the score is 36-30, Bando to Deimon.

Deimon beats the Spiders and are going to the Kanto Tournament, where the high-school champs of Kanto face each other to choose who will go to the Christmas Bowl.

A "halftime show" of short player stories, interspersed with shorts.

The Cream Puff Tournament is a tournament in America where four teams representing different continents face each other.

Panther and a couple of the Devil Bats play a street game against a rival neighborhood to help Panther regain his love of football.

Sena takes up wrestling in order to try to defeat Ivan's mammoth tackle.

The Huh-Huh brothers take on a bull in order to train for the Creme Puff Cup.

Devil Bats vs. Savanna Survivors; in the end, the Devil Bats easily win; after seeing the Devil Bats practice, Panther, Homer, and the others decide to get Coach Apollo back.

Devil Bats vs. Blizzards; trailing 17-0 after the first half, the Blizzards send in their secret weapon to injure Sena.

Ivan's twin brother Wan has been placed on the field with current goals.

A recap of the fall tournament.

The challenge to the death game starts; the first team to play against are the Hashiratani Deers; Kurita must prepare to defeat his long time hero Onihei.

Game two of the Death Game; Zokugaku goes against Deimon; using only 1st year students, Deimon tries to beat the Chameleons.

Deimon has a school festival; a contest takes place.

Sena starts having nightmares about football.

The regional champions go to a place where they decide which regional teams will play against who for the Christmas Bowl.

Sena, Monta, and Suzuna visit Mizumachi in the hospital.

Kyoshin and Bando team up to beat Deimon in the third death game.

In the fourth death game against the Taiyo Spinx, Deimon is short-handed after Jumonji gets arrested for beating up some punks who were harassing a young girl.

Deimon vs. the NASA Aliens.

An interview with Hiruma and Agon; Sena protects Mamori from Agon.

A recap of the Shinryuji and Hiruma, Kurita, and Musahi's involvement.

The Devil Bats are given a night cruise on a ship to relax before the game.

Monta battles Ikkyu in a catching battle; Monta loses but vows to beat Ikkyu next time with 100% effort.

Unsei explains to Sena and the others why he trains so hard.

Finally, the match with Shinryuji is about to begin.

The game begins; Shinryuji gets the lead on Deimon.

The first half ends with 32-0, Shinryuji in the lead.

Hiruma tells Sena that he has to blitz Agon on every play, but it just does not seem to work.

Shin comments that even though each individual in Deimon is lacking, as a team they are already regarded as the strongest in Kanto, hinting the result of the game.

Sena grabs the ball and is about to score a touchdown, but Agon gets in the way.

Fifty-eighth seconds remain on the clock with the score at 35-28.

It turns out that before the tackling down of Monta, he reached his hand out and grabbed the grass on the out of bounds area.

After winning the game, the players line up to shake hands.

The Hakushu Dinosaurs play against the Taiyo Sphinx.

Seibu Wild Gunmen vs. Misaki Wolves.

Riku loses his cool and gets angry at the Wolves.

As a celebration of their progress, Mamori decides to buy Sena and Riku new shoes.

Ojo White Knights vs. Sado Strong Golems.

Hiruma and the rest of the team go to spy on Ojo at their high school festival; somebody traps Hiruma, Kurita, and Musashi while doing a quiz show.

Torakichi realizes that Sakuraba's not the ace of Ojo.

A few days before the game between Deimon and Ojo, Hiruma takes the team on a helicopter trip to remind them where Ojo is weakest.

Interviewing the two teams' catchers and running backs the day before the match.

It's the match between the Ojo White Knights and Deimon Devil Bats.

The battle between Ojo and Deimon has started, and Deimon gets to attack first.

Ikari makes his debut play.

Monta catches all the passes of Hiruma.

The Bats are on their fourth down and 40 yards away from the goal.

Takami once again tells Deimon which direction he will be running The Ballista.

Shin stops the passing game of Deimon, forcing them to use Sena.

Having achieved the speed of light as well, Shin declares himself the winner of the battle between him and Sena.

Hiruma and Mamori review the game's footage to find a strategy.

Sena uses a speed-boost to compete in power with Shin who knocks him away with some effort, giving Hiruma the chance to tackle the runner.

Ojo throws a long pass; Monta intercepts it without turning around to watch the ball.

Sakuraba attempts the Devil Backfire, but fails and makes a nasty fall losing consciousness.

The score is 20-13, Ojo to Deimon.

Deimon makes a safety, making the score 20-15 and getting the ball back.

There are three yards until the goal line and 1:21 on the clock left.

Shin successfully makes the final touchdown for White Knights, making the score 27-22 to the White Knights.

The final play comes down to Sena against Shin, one-on-one.