A family of victims from a house fire is rushed to Gaffney; Lenox fights to save two sisters injured in an all-night rave turned tragedy; tensions mount between Goodwin and Abrams over difficult staffing changes.

Things get personal when Ripley and Archer butt heads over the treatment plans tied to an unusual case. Asher makes a surprising discovery with an expectant couple. A patient throws the hospital into chaos.

Lenox and Frost receive an unusual request from the parents of a patient on life support. Ripley and Charles work with a man who can't remember who he is.

Charles races to convince a patient to accept treatment before it's too late. Frost bonds with a young girl battling immunodeficiency. Lenox makes a chilling discovery.

A personal clash between Asher and Archer reaches a breaking point. Charles and Ripley uncover a rare neurological disorder in a patient. Goodwin's personal life is put to the test.

Secrets are uncovered when Goodwin's family comes together for Bert. Ripley and Frost treat two children stung by hornets in a treehouse. A member of the team struggles with relationship woes.

Fire victims rush to Gaffney. Lenox treats two sisters hurt at a deadly rave. Conflict grows between Goodwin and Abrams.

The doctors deal with the professional and personal fallout from the choices made during the citywide blackout.

Tensions spike when a road rage incident sends three patients into the E.D. Frost's former television co-star resurfaces. An unexpected arrival catches Asher and Archer off guard.

Frost and Archer face a troubling medical mystery while treating a college basketball star. Lennox's treatment of a surrogate patient leads to complications for the patient and her best friend.

Old resentments stir up Charles when old friends from medical school visit. Asher is forced to overcome obstacles in the treatment of one of her patients. Ripley looks to honor his old friend, Sully.

Charles mentors three medical students for a day. Goodwin prepares for a crucial board meeting. Frost confronts his past.

A fire crew responds to an airfield when a passenger plane goes silent. What they discover reveals a far larger and deadlier secret with far-reaching consequences that threatens countless lives.

Archer and Lenox care for two friends hurt during St. Patrick's Day celebrations, while Hannah and Ripley treat a woman going through a difficult divorce.